Base de datos : MEDLINE Búsqueda : C05.550.323 [Categoria DeCS] Referencias encontradas : 1837 [refinar] Mostrando: 1 .. 10   en el formato [Largo]

página 1 de 184

va a la página

1 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19648626 Autor: Lombardi AV; Nett MP; Scott WN; Clarke HD; Berend KR; O'Connor MI Dirección: Joint Implant Surgeons, Inc., 7277 Smith's Mill Road, Suite 200, New Albany, OH 43054, USA. lombardiav@joint-surgeons.com Título: Primary total knee arthroplasty. Fuente: J Bone Joint Surg Am; 91 Suppl 5:52-5, 2009 Aug. ISSN: 1535-1386 País de publicación: United States Idioma: eng Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T

2 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19578745 Autor: Ishii H; Choudhuri R; Mathias A; Sowers AL; Flanders KC; Cook JA; Mitchell JB Dirección: Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1002, USA. Título: Halofuginone mediated protection against radiation-induced leg contracture. Fuente: Int J Oncol; 35(2):315-9, 2009 Aug. ISSN: 1019-6439 País de publicación: Greece Idioma: eng Resumen: Fibrosis of normal tissues often accompanies radiation treatment of cancer. Activation of the transforming growth factor-beta (TGF-beta) signaling pathway is thought to play a major role in radiation-induced fibrosis and has prompted the development and assessment of low molecular weight inhibitors of the pathway. Previous studies with halofuginone have shown it to inhibit TGF-beta signaling in vitro and protect mice from radiation-induced leg contraction (a model for soft tissue fibrosis). The current study confirms these findings for HaCaT cells stimulated with exogenous TGF-beta treatment. Reducing the halifuginone treatment from 7 days/week (used previously) to 5 days/week post-radiation exposure provided significant protection against radiation-induced leg contraction in mice 3 and 4 months post-radiation treatment. Halofuginone treatment was shown to attenuate TGF-beta signaling molecules taken from irradiated skin including TGF-betaRII, pSmad3, Smad7, and TSP1. The latter, TSP1, a co-activator of TGF-beta may serve as a suitable biomarker for monitoring the efficacy of halofuginone should it be evaluated in a clinical setting for protection against radiation-induced fibrosis. Tipo de publicación: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL Nombre de substancia: 0 (Piperidines); 0 (Quinazolinones); 0 (Receptors, Transforming Growth Factor beta); 0 (Transforming Growth Factor beta); 17395-31-2 (halofuginone); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.30 (transforming growth factor-beta type II receptor)

3 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19437068 Autor: Cunningham B; McCue J Dirección: Division of Plastic and Reconstructive Surgery, University of Minnesota Medical School, Mayo Memorial Bldg., 420 Delaware Street SE, Minneapolis, MN 55455, USA. cunni001@umn.edu Título: Safety and effectiveness of Mentor's MemoryGel implants at 6 years. Comentario: Erratum In:Aesthetic Plast Surg. 2009 May;33(3):439 Fuente: Aesthetic Plast Surg; 33(3):440-4, 2009 May. ISSN: 1432-5241 País de publicación: United States Idioma: eng Resumen: BACKGROUND: In November 2006, the FDA approved the Premarket Approval PMA applications for the round, cohesive, silicone gel-filled breast implants of Mentor (MemoryGel) and Allergan. Since that time, the devices have been widely available to plastic surgeons and their use is rapidly eclipsing that of the saline breast implants. Patients in the Core clinical studies supporting these approvals continue to be followed through for 10 years, with comprehensive annual patient and physician-reported evaluations of safety and efficacy. METHODS: One thousand and eight (1,008) female patients had data collected on 1,898 implants, and were enrolled at 48 sites. Key complication rates were recorded with Kaplan-Meier estimated cumulative incidence calculation for each. RESULTS: Rupture rate, suspected and confirmed, for primary augmentation was 1.1% (95% CI, 0.3-4.3), and that for primary reconstruction patients was 3.8% (95% CI, 1.4-9.8). Capsular contracture rates for clinically significant Baker III/IV contracture for primary augmentation was 9.8% (95% C I, 7.6-12.7), and that for primary reconstruction was 13.7% (95% CI, 9.7-19.1). The reoperation incidence for primary augmentation and primary reconstruction was 19.4 and 33.9%, respectively, with explantation and replacement with a study device in 3.9% of primary augmentations and 10.4% of primary reconstructions. CONCLUSIONS: Mentor MemoryGel Silicone Breast implants represent a safe and effective choice for women seeking breast augmentation or breast reconstruction following mastectomy. Tipo de publicación: JOURNAL ARTICLE

4 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19448352 Autor: Woratanarat P; Dabney KW; Miller F Dirección: Mahidol Universitesiniversitesi Tip Fakültesi Ramathibodi Hastanesi Ortopedi Klinigi, Bangkok, Tayland. Título: [Knee capsulotomy for fixed knee flexion contracture] Título: Kalici diz fleksiyon kontraktüründe kapsülotomi.. Fuente: Acta Orthop Traumatol Turc; 43(2):121-7, 2009 Mar-Apr. ISSN: 1017-995X País de publicación: Turkey Idioma: tur Resumen: OBJECTIVES: This study aimed to assess the results of knee capsulotomy for correcting fixed knee flexion contracture in children with cerebral palsy (CP). METHODS: Thirty-five children (20 boys, 15 girls; mean age 13.5+/-2.5 years) with CP underwent posterior knee capsulotomy for 59 knees. Eleven patients had diplegia, one patient had hemiplegia, and 23 patients had quadriplegia. There were two community ambulators (3 knees), 19 household ambulators (33 knees), and 14 nonambulators (23 knees). Posterior knee capsulotomy was combined with hamstring lengthening (50 knees, 84.8%), rectus femoris transfer (10 knees, 17%), Achilles tendon lengthening (12 knees, 20.3%), and posterior cruciate ligament release (eight knees, 13.6%). The mean follow-up was 3.5+/-1.7 years. RESULTS: Fixed knee flexion contracture significantly improved from 26.5+/-15.4 degrees to 17.0+/-15.5 degrees after posterior knee capsulotomy (p<0.0001). The mean improvement was 9.5 degrees. Popliteal angle significantly improved from 70.6+/-18.7 degrees to 48.2+/-19.9 degrees (p<0.0001). Ankle dorsiflexion did not differ significantly. At the end of follow-up, 38 knees (64.4%) had improved knee flexion contracture and 21 knees (35.6%) had recurrent flexion contracture (failure). Age and male gender were significantly associated with failure rate (adjusted odds ratio 0.78, 95% CI: 0.62-0.99 and 12.1, 95% CI: 2.37-61.7, respectively). Complications included transient sciatic nerve palsy in seven knees (11.9%), and wound dehiscence in two knees (3.4%). Revision was required in two knees (3.4%), and posterolateral corner reconstruction in one knee (1.7%). CONCLUSION: Posterior knee capsulotomy is another option for the treatment of knee contracture in CP, resulting in a significant decrease in knee contracture with acceptable complications. However, failure rate is higher in boys, patients who are marginal ambulators, and in younger age group. Tipo de publicación: ENGLISH ABSTRACT; JOURNAL ARTICLE

5 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19448351 Autor: Temelli Y; Akalan NE Dirección: Istanbul Universitesi Istanbul Tip Fakultesi, Ortopedi ve Travmatoloji Anabilim Dali, 34093 Capa, Istanbul, Turkey. ytemelli@gmail.com Título: [Treatment approaches to flexion contractures of the knee] Título: Diz fleksiyon kontraktüründe tedavi yaklasimlari.. Fuente: Acta Orthop Traumatol Turc; 43(2):113-20, 2009 Mar-Apr. ISSN: 1017-995X País de publicación: Turkey Idioma: tur Resumen: The knee is the most affected joint in children with cerebral palsy. Flexion contracture of the knee is the cause of crouch gait pattern, instability in stance phase of gait, and difficulties during standing and sitting, and for daily living activities. It may also cause patella alta, degeneration of the patellofemoral joint, and stress fractures of the patella and tibial tubercle in young adults. Children with cerebral palsy may even give up walking due to its high energy demand in the adult period. The purpose of this article is to review the causes of the knee flexion contractures, clinical and radiological evaluations, and treatment principles in children with cerebral palsy. The biomechanical reasons of knee flexion deformity are discussed in detail in the light of previous studies and gait analysis data. Tipo de publicación: ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW

6 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19332160 Autor: Pariani MJ; Spencer A; Graham JM; Rimoin DL Dirección: Medical Genetics Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. mitchel.pariani@cshs.org Título: A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. Fuente: Eur J Med Genet; 52(2-3):123-7, 2009 Mar-Jun. ISSN: 1878-0849 País de publicación: Netherlands Idioma: eng Resumen: We report a child with a 785kb deletion of the 3p14.1p13 region including the genes FOXP1, EIF4E3, PROK2, GPR27 resulting in speech delay, contractures, hypertonia and blepharophimosis. FOXP1 and FOXP2 are transcription factors containing a polyglutamine tract and a forkhead DNA binding domain. They both play a role in the developing human foregut and brain [W. Shu, M.M. Lu, Y. Zhang, P. Tucker, D. Zhou, E.E. Morrisey, Foxp2 and Foxp1 cooperatively regulate lung and esophagus development, Development 134 (2007) 1991-2000, E. Spiteri, G. Konopka, G. Coppola, J. Bomar, M. Oldham, J. Ou, et al. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain, Am. J. Hum. Genet. 81 (2007) 1144-1157, S. Tamura, Y. Morikawa, H. Iwanishi, T. Hisaoka, E. Senba. Expression pattern of the winged-helix/forkhead transcription factor Foxp1 in the developing central nervous system, Gene Expr. Patterns. 3 (2003) 193-197.]. Mutations in FOXP2 are known to cause severe speech and language abnormalities [C.S.L. Lai, S.E. Fisher, J.A. Hurst, F. Vargha-Khadem, A.P. Monaco, A forkhead-domain gene is mutated in a severe speech and language disorder, Nature 413 (2001) 519-523.] in humans and animals. It has been suggested that overlap of FOXP1 and FOXP2 expression in the songbird and human brain may indicate that mutations in FOXP1 would also result in speech and language abnormalities. The roles of EIF4E3, PROK2 and GPR27 are also evaluated. Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE Nombre de substancia: 0 (FOXP1 protein, human); 0 (Forkhead Transcription Factors); 0 (Repressor Proteins)

7 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19280247 Autor: Khan UD Dirección: Belvedere Private Hospital, Knee Hill Abbeywood, London, SE2 0GD, UK. Mrumarkhan@aol.com Título: Dynamic breasts: a common complication following partial submuscular augmentation and its correction using the muscle-splitting biplane technique. Fuente: Aesthetic Plast Surg; 33(3):353-60, 2009 May. ISSN: 1432-5241 País de publicación: United States Idioma: eng Resumen: BACKGROUND: Dynamic breast deformity following partial submuscular augmentation is not uncommon. The complication is due primarily to the release of the pectoralis and the true incidence of this complication is not known. The submuscular biplane pocket is a new pocket and is used to correct dynamic breasts following augmentation mammaplasty in the partial submuscular plane. METHODS: After the first submuscular biplane muscle-splitting augmentation mammaplasty in October 2005, the author has performed 58 secondary augmentation mammaplasties for various reasons. Of these, nine patients showed marked dynamic breast deformity following partial submuscular augmentation and the submuscular muscle-splitting biplane was used to correct this complication. RESULTS: Good to excellent results were achieved in all patients with complete elimination of the dynamic breast deformity. CONCLUSION: The submuscular biplane is a new and versatile pocket and is used to correct dynamic breast deformity seen following partial submuscular augmentation mammaplasty. Tipo de publicación: JOURNAL ARTICLE

8 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19506506 Autor: Grishkevich VM Dirección: Department of Reconstructive and Plastic Surgery, A.V. Vishnevsky Institute of Surgery of the Russian Academy of Medical Sciences, Moscow, Russia. Título: Burned perineum reconstruction: a new approach. Fuente: J Burn Care Res; 30(4):620-4, 2009 Jul-Aug. ISSN: 1559-047X País de publicación: United States Idioma: eng Resumen: The treatment of postburn contractures of perineum remains a complex and an unsolved problem. Fourteen patients were operated. According to our observations, the perineum contracture can have two formations: (a) transverse scar folds formed between both the thighs and (b) obliteration of perineum by scar tissues. The first type, most common, is successfully eliminated by using local trapezoid flaps. The flaps are prepared from the divided sheets and adjacent tissues on both inner thighs' surfaces. The flaps are performed by cross-incisions of the fold; several pairs of adipose-scar flaps are formed. Because of the crescent shape of the fold, the flaps acquire a trapezoid shape. Then, they are transposed toward each other without rotation, doubling the surface of maximum tension thus eliminating the contracture completely. This technique allows releasing the contracture without skin grafting. The flaps are 4 to 5 cm wide, and they contain subcutaneous fat layer and have no sharp angles. All this assures stable circulation and prevents necrosis, flap loss, and contracture recurrence. Tipo de publicación: JOURNAL ARTICLE

9 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19506495 Autor: Cil Y; Yapici AK; Kocman AE; Ozturk S Dirección: Department of Plastic Surgery, Eskisehir Military Hospital, Eskisehir, Turkey. Título: Distally based venous flap for proximal phalangeal soft tissue burn defect and web space burn contracture. Fuente: J Burn Care Res; 30(4):643-7, 2009 Jul-Aug. ISSN: 1559-047X País de publicación: United States Idioma: eng Resumen: Flap choices for the coverage of the proximal phalangeal soft tissue defects of the finger and web space burn contractures are limited. A unipedicled distally based venous flap was raised from the third or fourth metacarpal area of the hand for proximal phalangeal soft tissue defects of the finger and web space burn contracture. For clinical use, we operated seven male patients using this venous flap. Superficial necrosis involving two flaps did not interfere with flap survival. Mild edema and venous congestion occurred in all flaps. All flaps survived completely. The mean follow-up period of the flaps was 6 months, ranging from 3 to 14 months. A well-planned distally based venous flap is an useful option for the coverage of the proximal phalangeal soft tissue burn defects of the finger and web space burn contracture of the hand. Tipo de publicación: CASE REPORTS; JOURNAL ARTICLE

10 / 1837

MEDLINE

selecciona para imprimir Fotocopia

PMID: 19506493 Autor: Richard RL; Lester ME; Miller SF; Bailey JK; Hedman TL; Dewey WS; Greer M; Renz EM; Wolf SE; Blackbourne LH Dirección: United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA. Título: Identification of cutaneous functional units related to burn scar contracture development. Fuente: J Burn Care Res; 30(4):625-31, 2009 Jul-Aug. ISSN: 1559-047X País de publicación: United States Idioma: eng Resumen: The development of burn scar contractures is due in part to the replacement of naturally pliable skin with an inadequate quantity and quality of extensible scar tissue. Predilected skin surface areas associated with limb range of motion (ROM) have a tendency to develop burn scar contractures that prevent full joint ROM leading to deformity, impairment, and disability. Previous study has documented forearm skin movement associated with wrist extension. The purpose of this study was to expand the identification of skin movement associated with ROM to all joint surface areas that have a tendency to develop burn scar contractures. Twenty male subjects without burns had anthropometric measurements recorded and skin marks placed on their torsos and dominant extremities. Each subject performed ranges of motion of nine common burn scar contracture sites with the markers photographed at the beginning and end of motion. The area of skin movement associated with joint ROM was recorded, normalized, and quantified as a percentage of total area. On average, subjects recruited 83% of available skin from a prescribed area to complete movement across all joints of interest (range, 18-100%). Recruitment of skin during wrist flexion demonstrated the greatest amount of variability between subjects, whereas recruitment of skin during knee extension demonstrated the most consistency. No association of skin movement was found related to percent body fat or body mass index. Skin recruitment was positively correlated with joint ROM. Fields of skin associated with normal ROM were identified and subsequently labeled as cutaneous functional units. The amount of skin involved in joint movement extended far beyond the immediate proximity of the joint skin creases themselves. This information may impact the design of rehabilitation programs for patients with severe burns. Tipo de publicación: JOURNAL ARTICLE

---

página 1 de 184

va a la página

Refinar la búsqueda

Base de datos : MEDLINE_1997-2009MEDLINE_1966-1996

Formulario avanzado

Buscar por : Formulario libre    Formulario básico

		Buscar	en el campo
1			PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloIdiomaPaís de publicaciónNombre de substanciaSímbolo de genNombre personal como asuntoRevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoActualización por claseAño de publicaciónCategoria DeCSTexto completo SciELOSubSetsPaís de AfiliaciónAfiliación
2	and or and not		PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloIdiomaPaís de publicaciónNombre de substanciaSímbolo de genNombre personal como asuntoRevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoActualización por claseAño de publicaciónCategoria DeCSTexto completo SciELOSubSetsPaís de AfiliaciónAfiliación
3	and or and not		PalabrasDescriptor de asuntoDescriptor de asunto primarioLímitesAutorPalabras del títuloIdiomaPaís de publicaciónNombre de substanciaSímbolo de genNombre personal como asuntoRevistaISSNTipo de publicaciónIdentificador únicoMes de ingresoActualización por claseAño de publicaciónCategoria DeCSTexto completo SciELOSubSetsPaís de AfiliaciónAfiliación

Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPS/OMS - Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud