Base de dados : MEDLINE
Pesquisa : H01.181 [Categoria DeCS]
Referências encontradas : 74659 [refinar]
Mostrando: 1 .. 10   no formato [Longo]

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  1 / 74659 MEDLINE  
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PMID:29368463
Autor:Stewart L
Título:Pneumatic Chemistry, Self-Experimentation and the Burden of Revolution.
Fonte:Clio Med; 95:139-69, 2016.
ISSN:0045-7183
País de publicação:Netherlands
Idioma:eng
Tipo de publicação: HISTORICAL ARTICLE; JOURNAL ARTICLE


  2 / 74659 MEDLINE  
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PMID:29195065
Autor:Cheng Y; Glaeser RM; Nogales E
Endereço:Department of Biochemistry and Biophysics, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Título:How Cryo-EM Became so Hot.
Fonte:Cell; 171(6):1229-1231, 2017 Nov 30.
ISSN:1097-4172
País de publicação:United States
Idioma:eng
Resumo:The Royal Swedish Academy of Sciences awarded the 2017 Nobel Prize for Chemistry to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution." Achieving this goal, which required innovation, persistence, and uncommon physical insight, has broadened horizons for structural studies in molecular and cell biology.
Tipo de publicação: BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
Nome de pessoa como assunto: Henderson R; Joachim F; Dubochet J
Nome de substância:0 (Proteins)


  3 / 74659 MEDLINE  
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PMID:28864201
Autor:Xu G; Ma T; Zang T; Sun W; Wang Q; Ma J
Endereço:School of Life Sciences, Tsinghua University, Beijing 100084, China.
Título:OPUS-DOSP: A Distance- and Orientation-Dependent All-Atom Potential Derived from Side-Chain Packing.
Fonte:J Mol Biol; 429(20):3113-3120, 2017 Oct 13.
ISSN:1089-8638
País de publicação:England
Idioma:eng
Resumo:We report a new distance- and orientation-dependent, all-atom statistical potential derived from side-chain packing, named OPUS-DOSP, for protein structure modeling. The framework of OPUS-DOSP is based on OPUS-PSP, previously developed by us [JMB (2008), 376, 288-301], with refinement and new features. In particular, distance or orientation contribution is considered depending on the range of contact distance. A new auxiliary function in energy function is also introduced, in addition to the traditional Boltzmann term, in order to adjust the contributions of extreme cases. OPUS-DOSP was tested on 11 decoy sets commonly used for statistical potential benchmarking. Among 278 native structures, 239 and 249 native structures were recognized by OPUS-DOSP without and with the auxiliary function, respectively. The results show that OPUS-DOSP has an increased decoy recognition capability comparing with those of other relevant potentials to date.
Tipo de publicação: JOURNAL ARTICLE


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PMID:28839061
Autor:Hunger J; Parekh SH
Endereço:Department of Molecular Spectroscopy, Max Planck Institute for Polymer Research, Mainz, Germany. hunger@mpipmainz.mpg.de parekh@mpip-mainz.mpg.de.
Título:A water window on surface chemistry.
Fonte:Science; 357(6353):755-756, 2017 08 25.
ISSN:1095-9203
País de publicação:United States
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE; COMMENT
Nome de substância:059QF0KO0R (Water)


  5 / 74659 MEDLINE  
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PMID:28644869
Autor:Kandel KP; Neupane BB; Giri B
Endereço:Department of Chemistry, Birendra Multiple Campus, Tribhuvan University, Chitwan, Nepal.
Título:Status of chemistry lab safety in Nepal.
Fonte:PLoS One; 12(6):e0179104, 2017.
ISSN:1932-6203
País de publicação:United States
Idioma:eng
Resumo:Chemistry labs can become a dangerous environment for students as the lab exercises involve hazardous chemicals, glassware, and equipment. Approximately one hundred thousand students take chemistry laboratory classes annually in Nepal. We conducted a survey on chemical lab safety issues across Nepal. In this paper, we assess the safety policy and equipment, protocols and procedures followed, and waste disposal in chemistry teaching labs. Significant population of the respondents believed that there is no monitoring of the lab safety in their lab (p<0.001). Even though many labs do not allow food and beverages inside lab and have first aid kits, they lack some basic safety equipment. There is no institutional mechanism to dispose lab waste and chemical waste is disposed haphazardly. Majority of the respondents believed that the safety training should be a part of educational training (p = 0.001) and they would benefit from short course and/or workshop on lab safety (p<0.001).
Tipo de publicação: JOURNAL ARTICLE


  6 / 74659 MEDLINE  
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PMID:28538715
Autor:Tian P; Murphy F
Título:Close range.
Fonte:Nature; 545(7655):S46-S49, 2017 05 24.
ISSN:1476-4687
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE


  7 / 74659 MEDLINE  
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PMID:28475312
Autor:Krallinger M; Rabal O; Lourenço A; Oyarzabal J; Valencia A
Endereço:Structural Computational Biology Group, Structural Biology and BioComputing Programme, Spanish National Cancer Research Centre , C/Melchor Fernández Almagro 3, Madrid E-28029, Spain.
Título:Information Retrieval and Text Mining Technologies for Chemistry.
Fonte:Chem Rev; 117(12):7673-7761, 2017 Jun 28.
ISSN:1520-6890
País de publicação:United States
Idioma:eng
Resumo:Efficient access to chemical information contained in scientific literature, patents, technical reports, or the web is a pressing need shared by researchers and patent attorneys from different chemical disciplines. Retrieval of important chemical information in most cases starts with finding relevant documents for a particular chemical compound or family. Targeted retrieval of chemical documents is closely connected to the automatic recognition of chemical entities in the text, which commonly involves the extraction of the entire list of chemicals mentioned in a document, including any associated information. In this Review, we provide a comprehensive and in-depth description of fundamental concepts, technical implementations, and current technologies for meeting these information demands. A strong focus is placed on community challenges addressing systems performance, more particularly CHEMDNER and CHEMDNER patents tasks of BioCreative IV and V, respectively. Considering the growing interest in the construction of automatically annotated chemical knowledge bases that integrate chemical information and biological data, cheminformatics approaches for mapping the extracted chemical names into chemical structures and their subsequent annotation together with text mining applications for linking chemistry with biological information are also presented. Finally, future trends and current challenges are highlighted as a roadmap proposal for research in this emerging field.
Tipo de publicação: JOURNAL ARTICLE; REVIEW


  8 / 74659 MEDLINE  
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PMID:28447653
Autor:Peplow M
Título:The next big hit in molecule Hollywood.
Fonte:Nature; 544(7651):408-410, 2017 04 26.
ISSN:1476-4687
País de publicação:England
Idioma:eng
Tipo de publicação: JOURNAL ARTICLE


  9 / 74659 MEDLINE  
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PMID:28417938
Autor:Prabhath MRR; Williams L; Bhat SV; Sharma P
Endereço:School of Chemistry, Joseph Banks Laboratories, University of Lincoln, Lincoln LN6 7DL, UK. ranga_prabhath@yahoo.com.
Título:Recent Advances in Cyanamide Chemistry: Synthesis and Applications.
Fonte:Molecules; 22(4), 2017 Apr 12.
ISSN:1420-3049
País de publicação:Switzerland
Idioma:eng
Resumo:The application of alkyl and aryl substituted cyanamides in synthetic chemistry has diversified multi-fold in recent years. In this review, we discuss recent advances (since 2012) in the chemistry of cyanamides and detail their application in cycloaddition chemistry, aminocyanation reactions, as well as electrophilic cyanide-transfer agents and their unique radical and coordination chemistry.
Tipo de publicação: JOURNAL ARTICLE; REVIEW
Nome de substância:0 (Metals); 420-04-2 (Cyanamide)


  10 / 74659 MEDLINE  
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PMID:28371105
Autor:Gautier A; Rodriguez R
Endereço:Ecole Normale Supérieure, 24 rue Lhomond, 75005, Paris, France.
Título:PSL Chemical Biology Symposia First 2016 Edition: When Chemistry and Biology Share the Language of Discovery.
Fonte:Chembiochem; 18(10):883-887, 2017 May 18.
ISSN:1439-7633
País de publicação:Germany
Idioma:eng
Resumo:Chemical biology, the science of understanding biological processes at the molecular level, has grown exponentially with the development of chemical strategies to manipulate and quantify biology with unprecedented precision. Recent advances presented at the Université Paris Sciences et Lettres symposium are discussed.
Tipo de publicação: JOURNAL ARTICLE
Nome de substância:0 (Molecular Probes)



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