|
|
| Id: |
11244458
|
| Autor: |
Lowe Jr WL; Rotimi CN; Luke A; Guo X; Zhu X; Comuzzie AG; Schuh TS; Halbach S; Kotlar TJ; Cooper RS. |
| Título: |
The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans..
|
| Fonte: |
Int J Obes Relat Metab Disord;25(1):54-60, 2001 Jan.
|
| Resumo: |
OBJECTIVE: To examine the role of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene and the beta 3-adrenergic receptor gene locus in obesity-related traits in African Americans. SUBJECTS: A total of 687 individuals representing 193 African American families who were residents of metropolitan Chicago. MEASUREMENTS: Genotyping of the Trp64Arg polymorphism in the beta 3-adrenergic receptor gene and three microsatellite markers flanking the beta 3-adrenergic receptor gene (ADRB3) locus and measuring various obesity-related traits, including body mass index (BMI), fat-free mass, fat mass, percentage fat mass, waist circumference and serum lipid levels. RESULTS: The prevalence of obesity (defined as body mass index > or = 30 kg/m(2)) in the population was 27.3% and 51.2% in men and women, respectively. The frequency of the Arg64 allele was 10.0%. Multivariate regression analyses confirmed the existence of a significant contribution of familial variance to each of the five obesity-related traits noted above. Likelihood ratio statistics computed in a multivariate regression analysis failed to demonstrate a significant association between the Arg64 allele and any of the five obesity-related traits. Single and multipoint analyses using extended Haseman--Elston regression analyses failed to demonstrate suggestive evidence of linkage of three microsatellite markers that flank the beta 3-adrenergic receptor gene to BMI, percentage body fat, waist circumference or serum leptin levels. CONCLUSION: Given the contribution of familial variance to obesity-related traits in this population, neither the null finding for the Arg64 allele nor the lack of evidence of linkage of the ADRB3 locus to obesity-related traits could be attributed to lack of transmissibility of the traits suggesting that neither the Arg64 variant of the beta 3-adrenergic receptor gene nor another genetic variant in or near the ADRB3 locus contribute significantly to familial aggregation of obesity-related traits in African Americans. International Journal of Obesity (2001) 25, 54-60.
|
| Descritores: |
Grupo com Ancestrais do Continente Africano/genética
Obesidade/genética
Receptores beta-3 Adrenergicos/genética
|
| |
-Tecido Adiposo
Adolescente
Adulto
Idoso
Índice de Massa Corporal
Peso Corporal/genética
Feminino
Freqüência do Gene
Genótipo
Humanos
Illinois/epidemiologia
Leptina/sangue
Lipídeos/sangue
Masculino
Meia-Idade
Obesidade/epidemiologia
Polimorfismo Genético/genética
Prevalência
Análise de Regressão
|
| Responsável: |
BR1.1 - BIREME |
|
