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Amodeo, Celso
Id: lil-148737
Autor: Amodeo, Celso; Barros, Lena Maria de Souza; Batlouni, Michel; Sousa, J. Eduardo M. R.
Título: Efeito anti-hipertensivo de urapidil em hipertensäo arterial leve a moderada: estudo randomizado, duplo-cego, contra placebo / Antihypertensive effect of urapidil in mild to moderate arterial hypertension: randomized, double-blind versus placebo study
Fonte: Arq. bras. cardiol;61(2):127-30, ago. 1993. tab.
Idioma: pt.
Resumo: PURPOSE--To evaluate the efficacy and tolerability of urapidil (a new central and peripheral antihypertensive agent) in patients with mild to moderate essential hypertension. METHODS--Thirty-one patients were randomized, double-blindly, to receive either placebo (15 patients) or urapidil (16 patients) for 3 months. The initial dose of urapidil was 30mg twice daily, per oral. The dose was increased progressively till achievement of good blood pressure control or the dose of 60mg three times a day. RESULTS--Seventy percent of the patients on urapidil group responded to therapy against 30 per cent on the placebo group. There were 3 cases of hypertensive crises (2 on urapidil and 1 on placebo) on the early therapy. The adverse events with urapidil were unfrequent and the most common were headache and dizziness. There were no modification on blood sugar and lipids level. CONCLUSION--Urapidil appears to be a safe antihypertensive agent in the treatment of mild to moderate essential hypertension. It also did not demonstrate any clinical effect on the carbohydrates and lipids profile
Descritores: Anti-Hipertensivos/uso terapêutico
Hipertensão/tratamento farmacológico
Piperazinas/uso terapêutico
Pressão Arterial
-Método Duplo-Cego
Hipertensão/fisiopatologia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Tipo de Publ: Ensaio Clínico
Ensaio Clínico Controlado Aleatório
Estudo Comparativo
Responsável: BR1.1 - BIREME



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