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| Id: |
332492
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| Autor: |
Primo, V; Rovera, M; Zanon, S; Oliva, M; Demo, M; Daghero, J; Sabini, L. |
| Título: |
Determinación de la actividad antibacteriana y antiviral del aceite esencial de Minthostachys verticillata (Griseb. ) Epling / Determination of the antibacterial and antiviral activity of the essential oil from Minthostachys verticillata (Griseb. ) Epling
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| Fonte: |
Rev. argent. microbiol;33(2):113-117, abr.-jun. 2001.
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| Idioma: |
Es.
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| Resumo: |
The in vitro antiviral activity of the essential oil from Minthostachys verticillata was investigated against herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PrV). The viral inhibition was assayed employing viral plaque reduction assay. The antiviral activity of the essential oil specifically affects PrV and HSV-1 multiplication, since it was found that non toxic effects on cells were observed at the concentrations assayed. The therapeutic index values were 10.0 and 9.5 for HSV-1 and PrV, respectively. The antibacterial activity was studied using a diffusion assay and the broth tube dilution method. Gram-positive bacteria were more sensitive to inhibition by plant essential oil than the gram-negative bacteria. The essential oil of M. verticillata was analyzed by gas chromatography (GC) technique. Of the six components identified in the volatile oil, pulegone (44.56) and menthone (39.51) were the major constituents. The antimicrobial activity can be explained to some extent by the presence of pulegone. Results suggest that further investigations concerning the isolation of the substance responsible for the antimicrobial activity and an effort to define the mechanisms of action are warranted.(AU)
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| Descritores: |
Agentes Antibacterianos/farmacologia
Antivirais/farmacologia
Bactérias Gram-Negativas/efeitos de drogas
Bactérias Gram-Positivas/efeitos de drogas
Herpesvirus Suídeo 1/efeitos de drogas
Óleos Vegetais/farmacologia
Plantas Medicinais/química
Simplexvirus/efeitos de drogas
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-Bacillus cereus/efeitos de drogas
Cromatografia Gasosa
Escherichia coli/efeitos de drogas
Herpesvirus Suídeo 1/fisiologia
Mentol/análogos & derivados
Mentol/isolamento & purificação
Mentol/farmacologia
Testes de Sensibilidade Microbiana
Óleos Vegetais/química
Ensaio de Placa
Proteus mirabilis/efeitos de drogas
Pseudomonas aeruginosa/efeitos de drogas
Simplexvirus/fisiologia
Staphylococcus aureus/efeitos de drogas
Terpenos/isolamento & purificação
Terpenos/farmacologia
Replicação Viral/efeitos de drogas
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| Responsável: |
BR1.1 - BIREME
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