Síndrome hemolítico urémico en Chile: presentación clínica, evolución y factores pronósticos / Hemolytic-uremic syndrome in Chile: clinical features, evolution and prognostic factors
Rev. méd. Chile
; 136(10): 1240-1246, Oct. 2008. graf, tab
Artigo
em Espanhol
| LILACS
| ID: lil-503890
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
Hemolytic-uremic syndrome (HUS) is characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia.Aim:
To describe the characteñstics ofpatients with the diagnosis ofHUS in Chile, and to identify the most reliable early predictors oímorbidity and moñality. Material andmethods:
The clinical records ofpatients with HUS aged less than 15 years, attended between January 1990 and December 2003 in 15 hospitals, were reviewed. Demographic, clinical, biochemical, hematological parameters, morbidity and mortality were analyzed.Results:
A cohort of 587 patients aged 2 to 8 years, 48 percent males, was analyzed. Ninety two percent had diarrhea. At the moment of diagnosis, anuria was observed in 39 percent of the patients, hypertension in 45 percent and seizures in 17 percent. Forty two percent required renal replacement therapy (RRT) and perítoneal dialysis was used in the majoríty of cases (78 percent). The most frequently isolated etiological agentwas Escherichia coli. Mortality rate was 2.9 percent in the acute phase of the disease and there was a positive correlation between mortality and anuria, seizures, white blood cell count (WCC) >20.000/mm³ and requirements of renal replacement therapy (p <0.05). Twelve percent of patients evolved to chronic renal failure and the risk factors during the acute phase were the need for renal replacement therapy, anuria, WCC >20.000/mm³, seizures and hypertension.Conclusions:
The present study emphasizes important clinical and epidemiological aspeets ofHUSin a Chilean pediatricpopulation.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Diarreia
Base de dados:
LILACS
Assunto principal:
Anuria
/
Injúria Renal Aguda
/
Síndrome Hemolítico-Urêmica
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2008
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Chile
Instituição/País de afiliação:
Clínica Santa María/CL
/
Hospital Clínico San Borja Arriarán/CL
/
Hospital Dr. Luis Calvo Mackenna/CL
/
Hospital Roberto del Río/CL
/
Hospital San Juan de Dios/CL
/
Hospital Sótero del Río/CL
/
Hospital de Carabineros/CL
/
Hospital de Niños Dr. Exequiel González Cortés/CL
/
Pontificia Universidad Católica/CL
/
Universidad de Chile/CL
